(CNN) – Two real-world studies released on Wednesday confirm the declining immunity provided by the two doses of Pfizer’s Govt-19 vaccine two months later, although protection against serious illness, hospitalization and death remains strong.
Studies, published in and from Israel and Qatar New England Journal of Medicine, Support the argument that even those who are fully vaccinated should take precautions against infection.
A Study in Israel It involved 4,800 health workers and showed that antibody levels dropped rapidly after two doses of vaccine “especially among men, 65 and older, and those with immunodeficiency.”
“We conducted this long-term integrated study involving health workers at Sheba Medical Center, a large tertiary care center in Israel,” wrote Dr. Kili Rikave-Yochai de Sheba and colleagues.
Conditions known as neutralizing antibodies, the first line of the immune system against infection, are associated with protection against infection, but for this study they only examined antibody levels.
“The published work on many vaccines, such as measles, mumps and rubella, shows a slight decrease in the levels of neutralizing antibodies by 5 to 10% each year,” they wrote. “A rapid and significant decrease in the humorous response to the BNT162b2 vaccine was observed a few months after vaccination.”
The study also pointed out that the immunity of individuals who are naturally vaccinated after Govt-19 infection is prolonged. This is especially true for those who have been vaccinated after recovering from an infection. “Overall, the evidence gathered from our study and others shows that long-term humor response and the effectiveness of the vaccine in previously affected populations are superior to those receiving both vaccines,” they wrote.
One second Katta studyHe analyzed the real epidemics among the highly vaccinated population of that small Gulf country. The people there were mainly vaccinated against the Pfizer / BioNtech vaccine called PNT162b2.
“BNT162b2-induced protection increases rapidly after the first dose, peaks in the first month after the second dose, and then gradually decreases in subsequent months,” wrote Weil Cornell Medicine’s Light Abu-Radat. Qatar and his colleagues. “This decline appears to be rapid after the fourth month, reaching a low of about 20% in the following months,” they added.
Nonetheless, hospital and mortality protection is over 90%, they said.
Decreased security may be related to behavior, they noted. “Those who are vaccinated have a higher social contact rate than those who are not vaccinated, and are less likely to adhere to safety measures,” they wrote. “This behavior explains the reduced effectiveness of the vaccine in the real world compared to its biological effectiveness, and perhaps the reduced safety.”
But it is a sign that nations need to be prepared for the new wave of Govt-19. “These findings suggest that large sections of the vaccinated population may lose their protection against the disease in the coming months, possibly increasing the likelihood of new epidemics,” they wrote.
Pfizer argues that immunity from the first two doses of its vaccine begins to wear off after a few months. Last month, Pfizer received approval from the U.S. Food and Drug Administration (FDA) for booster doses of its vaccine for about six months after people had completed their first two doses.
The U.S. Centers for Disease Control and Prevention (CDC) recommends people over the age of 65 who are at high risk for infections, such as those who are severely ill with post-vaccine infections and health workers. And prisoners, receive reinforcements.
Israel is increasing its entire population, and now people are saying they should have a third vaccine.
In the United States, more than 6 million people have received a third dose of the vaccine, and CDC data show that the average rate of booster dose is higher than the rate of first-time vaccinated individuals.
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