January 19, 2022

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Reduces the immunity of the moderna and pfizer vaccines against Omigran

(CNN) – Immunization against the omigran variant of the corona virus is reduced by modern and Pfizer / Bioentech vaccines, but not less after natural infection. As analysts said on Friday.

The researchers say their findings show the need for vaccines that are particularly protective against the Omigran variant.

Doctor of the Icon School of Medicine in Mount Sinai, New York. Emilia Sortillo and her colleagues examined the blood of those who had been vaccinated, or encouraged to be vaccinated by Moderna or Pfizer / Bioendech, as well as the blood of victims. Recovered from Govt-19.

The Pfizer Covit-19 vaccine is being manufactured on September 22 at the Vaccine Clinic in Los Angeles. Credit: Frederick J. Brown / AFP / Getty Images

Although the experiments were performed on laboratory plates, the researchers said that their use of live viruses re-created real-life conditions. They sought out what are known as neutralizing antibodies – immune system structures that attach to the virus and prevent it from infecting cells. “In all 85 samples, the reduction in omigran neutralization was 14.5 times greater than in beta variant and original strain,” they wrote. “By comparison, there was only a four-fold reduction against beta in the same model.”

“In fact, 16.5% of the samples lost all neutralizing activity against Omigran.” This includes nearly three-quarters of blood samples from survivors of infections.

“Our findings support recent reports describing the vaccine’s significantly reduced protection against re-infection after two doses of BNT162b2 (Pfizer) and the almost nonexistent vaccine efficacy against symptomatic disease,” they wrote. However, those who received boosters from Pfizer had “75% order” protection.

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Researchers have not found any evidence that Moderna’s Govt-19 vaccine provides stronger protection than Pfizer. The blood of those who received two doses of the Pfizer / BioNTech vaccine produced 23 times fewer antibodies against the original strain of the virus, and the antibody levels of those who received the modern vaccine were 42 times higher. Small. For those receiving booster doses, the neutralizing activity was 7.5 times lower for the Pfizer / Bioentech vaccine and 16.7 times lower for the modern vaccine.

In general, antibody protection is related to real-life protection, but does not measure long-term protection against acute illness and death provided by slow-growing and more durable types of protection: immune cells. Called T cells.

“We need to keep in mind that the relationship between measurable neutralizing antibodies and the clinical course of an infection is not straightforward. In general, antibodies are necessary to prevent early infection; but cellular immunity – maintainable – is essential to prevent serious disease,” said Dr. Peter English, an epidemiologist in the UK. Said.

“Importantly, the study supports the notion that a third dose of the vaccine significantly improves the antibody response to the omigran infection,” English added. Who did not participate in the study.

Dr. Julian Tong of the University of Leicester, who was not involved in the study, said T-cell responses were important for long-term protection against serious diseases.

“The basic premise is that boosting existing immunity (whether vaccinated or naturally acquired) helps to protect against infection / re-infection to some extent, as well as boosting existing D-cell responses, all of which help protect us from omigran. It is important that you take these booster doses, especially. If you are in one of the vulnerable groups, “Tang said.

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